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Research record

Publications

Papers, preprints, chapters, commentaries, and conference contributions spanning computational biology, systems biology, genomics, and diagnostics.

27 records

2025
preprint

Deep Profiling of EV Long RNAs Reveals Biofluid-Specific Transcriptomes and Splicing Landscapes

Sudipto K. Chakrabortty; Shuran Xing; Sinead Nguyen; Allan George; Dulaney L. Miller; Kailey Babcock; Kyle Manning; T. Jeffrey Cole; Emily Mitsock; Christian J. Ray; Sivakumar Gowrisankar; Johan Skog

Preprint · 10.1101/2025.08.05.668716

2025
preprint

Salivary Extracellular Vesicle RNA Profiling Reveals Biomarkers for Sjögren’s

Sudipto K. Chakrabortty; Shuran Xing; Allan George; Benjamin Sawicki; Steven Lang; Sinead Nguyen; T. Jeffrey Cole; Emily Mitsock; Christian Ray; Driss Zoukhri; Mabi Singh; Loukas Chatzis; Andreas Goules; Maria-Ioanna Saridaki; Sivakumar Gowrisankar; Athanasios G Tzioufas; Athena Papas; Johan Skog

Preprint · 10.1101/2025.08.05.668729

2025
preprint

Extracellular Vesicle Gene Expression Enables Sensitive Detection of Colorectal Neoplasia

Sivakumar Gowrisankar; J. Christian J. Ray; Sinead Nguyen; Christopher J. Benway; Shuran Xing; Allan George; Dulaney L. Miller; Kyle Manning; Yang Yang; Jeff Cole; Emily Mitsock; Devin Perez; Luanna Dealmeida; Julia Doo; Pawan Kumar Upadhyay; Yiyuan Yao; Joseph M. Johnson; Brian C. Haynes; Sudipto K. Chakrabortty; Johan K. Skog

Preprint · 10.1101/2025.08.14.670394

2024
abstract

Stratification of patients with prostate cancer using a urine exosome gene expression signature

Dulaney Miller; Kyle Manning; Shuran Xing; T. Jeffrey Cole; Christopher J. Benway; Elena M. Cortizas; J. Christian J. Ray; Siva Gowrisankar; Sudipto Chakrabortty; Brian Haynes; Sandra M. Gaston; Seth Yu; Sanoj Punnen; Johan Skog

Journal of Clinical Oncology · 10.1200/jco.2024.42.16_suppl.e17095

2023
preprint

Signatures of antibiotic tolerance and persistence in response to divergent stresses

Huijing Wang; GW McElfresh; Nishantha Wijesuriya; Adam Podgorny; Andrew D. Hecht; J. Christian J. Ray

Preprint · 10.1101/2023.02.05.527212

2021
preprint

Overlapping stimulons arising in response to divergent stresses inEscherichia coli

Huijing Wang; GW McElfresh; Nishantha Wijesuriya; Adam Podgorny; Andrew D. Hecht; J. Christian J. Ray

Preprint · 10.1101/2021.12.17.473201

2020
commentary

Tasting the Terroir with Tsr

Adam R. Podgorny; J. Christian J. Ray

Biophysical Journal · 10.1016/j.bpj.2019.09.049

2019
preprint

A novel metric reveals previously unrecognized distortion in the analysis of scRNA-seq data

Timothy Hamilton; Breanne Sparta; Shamus Cooley; Samuel D. Aragones; J. Christian J. Ray; Eric J. Deeds

Preprint · 10.1101/689851

2019
paper

Diversity in lac Operon Regulation among Diverse Escherichia coli Isolates Depends on the Broader Genetic Background but Is Not Explained by Genetic Relatedness

Kelly N. Phillips; Scott Widmann; Huei-Yi Lai; Jennifer Nguyen; J. Christian J. Ray; Gábor Balázsi; Tim F. Cooper

mBio · 10.1128/mbio.02232-19

2018
paper

Lineage space and the propensity of bacterial cells to undergo growth transitions

Arnab Bandyopadhyay; Christopher V. Rao; Huijing Wang; J. Christian J. Ray

PLOS Computational Biology · 10.1371/journal.pcbi.1006380

2018
paper

Computation by natural systems

Dominique Chu; Mikhail Prokopenko; J. Christian J. Ray

Interface Focus · 10.1098/rsfs.2018.0058

2018
chapter

Intergenerational Cellular Signal Transfer and Erasure

G. W. C. McElfresh; J. Christian J. Ray

The Energetics of Computing in Life and Machines · 10.37911/9781947864078.05

2017
paper

Dynamical predictors of an imminent phenotypic switch in bacteria

Huijing Wang; J Christian J Ray

Physical Biology · 10.1088/1478-3975/aa7870

2016
paper

Survival of Phenotypic Information during Cellular Growth Transitions.

Ray JC

ACS synthetic biology · 10.1021/acssynbio.5b00229

2016
paper

Cellular Growth Arrest and Persistence from Enzyme Saturation.

Ray JC; Wickersheim ML; Jalihal AP; Adeshina YO; Cooper TF; Balázsi G

PLoS computational biology · 10.1371/journal.pcbi.1004825

2015
paper

Stress-response balance drives the evolution of a network module and its host genome.

González C; Ray JC; Manhart M; Adams RM; Nevozhay D; Morozov AV; Balázsi G

Molecular systems biology · 10.15252/msb.20156185

2015
paper

Amino acid positions subject to multiple coevolutionary constraints can be robustly identified by their eigenvector network centrality scores.

Parente DJ; Ray JC; Swint-Kruse L

Proteins · 10.1002/prot.24948

2012
paper

Adaptive evolution of the lactose utilization network in experimentally evolved populations of Escherichia coli.

Quan S; Ray JC; Kwota Z; Duong T; Balázsi G; Cooper TF; Monds RD

PLoS genetics · 10.1371/journal.pgen.1002444

2012
paper

Interplay of gene expression noise and ultrasensitive dynamics affects bacterial operon organization.

Ray JC; Igoshin OA

PLoS computational biology · 10.1371/journal.pcbi.1002672

2011
paper

Bistable responses in bacterial genetic networks: designs and dynamical consequences.

Tiwari A; Ray JC; Narula J; Igoshin OA

Mathematical biosciences · 10.1016/j.mbs.2011.03.004

2011
paper

Non-transcriptional regulatory processes shape transcriptional network dynamics.

Ray JC; Tabor JJ; Igoshin OA

Nature reviews. Microbiology · 10.1038/nrmicro2667

2010
paper

Adaptable functionality of transcriptional feedback in bacterial two-component systems.

Ray JC; Igoshin OA

PLoS computational biology · 10.1371/journal.pcbi.1000676

2009
paper

Synergy between individual TNF-dependent functions determines granuloma performance for controlling Mycobacterium tuberculosis infection.

Ray JC; Flynn JL; Kirschner DE

Journal of immunology (Baltimore, Md. : 1950) · 10.4049/jimmunol.0802297

2008
paper

The timing of TNF and IFN-gamma signaling affects macrophage activation strategies during Mycobacterium tuberculosis infection.

Ray JC; Wang J; Chan J; Kirschner DE

Journal of theoretical biology · 10.1016/j.jtbi.2008.01.010

2008
paper

A methodology for performing global uncertainty and sensitivity analysis in systems biology.

Marino S; Hogue IB; Ray CJ; Kirschner DE

Journal of theoretical biology · 10.1016/j.jtbi.2008.04.011

2006
paper

Requirement for multiple activation signals by anti-inflammatory feedback in macrophages.

Ray JC; Kirschner DE

Journal of theoretical biology · 10.1016/j.jtbi.2005.11.037

1999
paper

The effect of phospholipids and mucin on bacterial internalization in an enterocyte-cell culture model.

Usui N; Ray CJ; Drongowski RA; Coran AG; Harmon CM

Pediatric surgery international · 10.1007/s003830050543